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Scientist I/Associate Scientist II - ImmunoOncology Research (FTC) AstraZeneca

Location: Cambridge, England, United Kingdom
Job reference: R-042453
Posted date: Jan. 09, 2019

Research Scientist (Associate Scientist II/ Scientist I), ImmunoOncology Research

Location: Cambridge; 12 months fixed term contract

Salary: Competitive

If you’re passionate about the possibilities of science to change lives and you thrive when making brave decisions – join us.

MedImmune is the worldwide biologics research and development arm of AstraZeneca. Here, you’ll have the opportunity to make a difference in people’s lives every single day. As one of the world’s premier biotechnology companies, our mission is centered on delivering life-changing products that advance world health, and help fight and cure disease.

As a Research Scientist within the Oncology Research group in Cambridge, UK you will be a key member of a highly successful team focussed on supporting immune-oncology projects through the drug discovery process. You will bring your theoretical and practical expertise in immunology to establish assay systems, and deliver datasets that will have direct impact on immune-oncology research projects.

AstraZeneca’s vision in Oncology is to help patients by redefining the cancer-treatment paradigm, with the goal of bringing six new cancer medicines to patients between 2013 and 2020. A broad pipeline of next-generation medicines is focused principally on four disease areas - breast, ovarian, lung and haematological cancers. As well as other tumour types, these are being targeted through four key platforms - immunotherapy, the genetic drivers of cancer and resistance, DNA damage repair, and antibody drug conjugates, underpinned by personalised healthcare and biomarker technologies.

MedImmune has a dynamic environment that fosters collaboration and innovation. We attract top minds, and we nurture and build top talent.

Main Duties and Responsibilities

Working in this laboratory-based position within the Immuno-Oncology Research group you will develop, design, conduct and analyse in vitro experiments to assess the function of our therapeutics and help to dissect the mechanism of action of novel therapeutics targeting the immune system for cancer therapy. You will also review emerging literature and internal data to help in identifying new potential targets and contribute to target validation activities.

A strong foundation in immunology / immuno-oncology, and depth of expertise in techniques for the analysis of immune function and phenotype is essential for this role. As a highly organised, ambitious individual with a strong lab/practical background you will stay up to date with relevant technical and intellectual scientific expertise in tumour immunology and biomarker discovery.

Essential Requirements

  • A PhD, or equivalent experience, in immunology and/or immuno-oncology.
  • Experience of a range of in vitro skills analysing human immune cell function e.g. multiparameter flow cytometry, ELISA, primary immune cell co-cultures, molecular biology skills including transcriptomics, assessment of intracellular signaling and generation of engineered cell lines
  • Strong interpersonal, influencing, negotiating and collaboration skills together with evidence of having used these to support problem solving and delivery in a team focussed, collaborative environment.
  • Depth of understanding and enthusiasm for immunology and immuno-oncology
  • Proven track record of success in your research
  • Data processing, statistical analysis and interpretation.
  • Experience preparing written scientific reports (e.g. manuscripts) and oral presentations (e.g. slides, posters).

Desirable Requirements

  • We would encourage applications from you if you have experience in immuno-metabolism, myeloid biology and/or bioinformatics (e.g. experience with transcriptomic data, visualizing/quantitating multi-parameter flow data).
  • Experience working with patient-derived tumours/TILs an advantage
  • Knowledge of the processes around drug discovery
  • Publications in top tier scientific journals

Next Steps – Apply today!

To be considered for this exciting opportunity, we ask you to please complete the full application on our website at your earliest convenience – it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity. If you know someone who would be a great fit, please share this posting with them.

MedImmune is an equal opportunity employer. MedImmune will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law.

Closing date for applications: 01/02/2019

Competitive remuneration and company benefits apply.